We have successfully organized the 11^th International Symposium on DNA-encoded Chemical Libraries on 7-8 Sept. 2023 at ETH Zurich and we are looking forward to the 12^th edition which will take place 12-13 Oct. 2024 in Shanghai:   

external page www.delsymposium.org

We are happy to announce that our DNA Encoded Library (DEL) group and external page WuXi AppTec HitS, a one-stop Target-to-Hit platform, entered into a Download research collaboration (PDF, 429 KB). The collaboration features new screening approaches for difficult targets and aims at further advancing DEL technology.

Recent publications

external page Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis Keller et al. Science (2024)

We present a novel method for the production of high-purity DNA-encoded chemical libraries using dual-linker solid-phase synthesis.

external page Assymetry of Dual-display DNA-encoded chemical libraries Plais, Trachsel, Scheuermann Bioconjugate Chem. (2024)

While dual-display DNA-encoded chemical libraries (DELs) are widely used for ligand discovery, their intrinsic asymmetry revealed by fluorescence polarisation experiments requires specific guidelines for effective on-DNA hit validation.